Seeing as how I lost my DS at PAX east and have been using a Loaner since, yup, gettin' one.
I'm sure the eyestrain isn't going to be an issue any more than other screens/portables or even books are. Just give your eyes a break from time to time and everything will be peachy.
As of Launch, I think I'm most looking forward to the AR card games... not too much else appeals to me. Maybe Pilotwings.